BEMÆRK: Ansøgningsfristen er overskredet
The Department of Biomedicine at Faculty of Health at Aarhus University invites applications for a position as Postdoc in the field of cancer, metabolic reprogramming and T cells as per 1 February 2024 or as soon as possible thereafter. The position is a fixed-term 3 year full-time position.
The department of Biomedicine prioritizes diversity and a good work environment, as this is a prerequisite for groundbreaking research. In a diverse and international research environment, dedicated employees are looking to generate new knowledge within biomedical research areas such as infection and inflammation, membranes, neuroscience and personalised medicine. The Department of Biomedicine provides research-based teaching of the highest quality and is responsible for a large part of the medical degree programme. Academic staff contribute to the teaching. English is the preferred language in the laboratory, at meetings and at seminars. The department employs approx. 500 people from all over the world, and they make use of the department's modern laboratory-, core- and animal facilities. The Department of Biomedicine focuses on innovation, entrepreneurship and collaboration with business and industry, and numerous researchers from the department have established companies to develop new medicinal treatments founded in professional scientific basic research. You can read more about the department here and about the faculty here.
About the research project
Recent scientific advancement in personalized cancer immunotherapy has demonstrated the effectiveness of collecting tumor infiltrating lymphocytes (TILs) from tumors and expand ex-vivo and deliver them back into the patient as a therapeutic agent. However, only a small portion of the ex vivo TILs are truly tumor-reacting TILs whereas the rest are bystander cells. This challenge warrants for solutions aiming for targeting of tumor-reactive TILs and reprogram them into long-lived effector cells. Emerging evidence indicate that exhausted TILs are partly a result of a distinct epigenetic reprogramming, where poor metabolic fitness of the T cells reinforce exhaustion. This can be a result of dysfunctional mitochondria and loss of biogenesis activity.
In this project – supported by a grant from Danish Cancer Society - we will explore if reversing of epigenetic-mediated metabolic fitness loss in T cells can promote re-proliferation and activation of tumor-reactive T cells and whether this can be targeted directly within the tumor microenvironment (TME).
Laboratory for Cancer, Immunity and Inflammation is led by Professor Martin R Jakobsen. The group is specialized in exploring the immune system in cancer and using cutting-edge technologies to identify novel therapeutics that manipulate the immune system and support stronger anti-tumoral effects. To know more about the group, please visit the homepage.
Your job responsibilities
We are seeking a highly motivated and talented Postdoctoral Researcher to join our dynamic research team focused on studying tumor-infiltrating lymphocytes (TILs), cancer metabolism, and metabolic reprogramming. As Postdoc in the group, your position is primarily research-based. You will be part of a rich intellectual and collaborative environment and have access to state-of-the-art facilities within the Department. The position offers an exciting opportunity to contribute to cutting-edge research in the field of cancer immunotherapy and metabolic regulation, with the goal of advancing our understanding of tumor immunology and developing innovative therapeutic strategies.
Your main responsibilities include:
- Design and execute experiments to investigate the role of T cells in the tumor microenvironment and their interaction with cancer cells.
- Develop and optimize protocols for expanding TILs from freshly collected tumor tissue.
- Characterize and analyze the metabolic profiles of TILs and cancer cells using state-of-the-art techniques such as metabolomics and single-cell RNAseq.
- Study the impact of metabolic reprogramming on TIL functions.
- Identify and validate potential targets for therapeutic intervention based on metabolic vulnerabilities in TILs.
- Collaborate with multidisciplinary teams to develop and evaluate novel strategies to modulate metabolic pathways in TILs.
- Analyze and interpret experimental data, present findings at scientific conferences, and contribute to scientific publications.
Your competences
You have academic qualifications at PhD level, preferably within one or more of the following areas: cancer immunology, tumor immunotherapy, and metabolic reprogramming.
Furthermore, we expect the applicant to have:
- Experience in studying TILs, T cell biology.
- Experience in conducting science within the field of cancer metabolism.
- Experience with tumor organoids, single cell RNAseq, and epigenetic reprogramming is highly desirable.
- Proven skill sets in CRISPR editing, lentiviral transduction and lipid nano particles delivery is highly relevant.
In order to be assessed as qualified for a Postdoc position, you must meet these academic criteria.
Shortlisting will be used.
Questions about the position
If you have any questions about the position, please contact Professor Martin R Jakobsen by email: mrj@biomed.au.dk.
Your place of work will be the Department of Biomedicine, 8000 Aarhus C, Denmark.
We expect to conduct interviews from December and onwards.
Terms of employment
- Appointment as a postdoc requires academic qualifications at PhD level.
- Further information on the appointment procedure can be found in the Ministerial Order on the Appointment of Academic Staff at Universities.
- The appointment is in accordance with the Danish Confederation of Professional Associations (Akademikerne).
- Remuneration is in accordance with the above, and the Salary agreement catalogue for staff at Health.
- The yearly base salary for a fulltime postdoc is between DKK 482.603,31 and DKK 536.927,17 depending on the years of working experience after achieved MSc degree. The base salary includes a position related supplement and pension (17.1 %). Additional supplement(s) for special qualifications can be negotiated. Authorisation supplemement(s) will be granted, if relevant for the position. Your local eligible trade union representative at Aarhus University negotiates your salary on your behalf.
- Researchers recruited from abroad are offered a special researcher tax scheme with a lower tax rate.
- Further information on qualification requirements and job description can be found in the Ministerial Order on Job Structure for Academic Staff
Application
Your application must include the following:
- Motivated application
- Curriculum Vitae
- Diploma
- Template for applicant - postdoc
- A list of publications
- A teaching portfolio. We refer to Guideline on the use of teaching portfolios
- A maximum of five of the publications of greatest relevance to the job may be submitted (optional)
- Research plan can be uploaded (optional)
- Coauthor statement(s) can be uploaded (optional)
- References/recommendations can be uploaded separately in the e-recruitment system (optional)
The assessment committee may decide to include non-submitted material in its statement. In such cases, you will be informed and obliged to submit material, unless your application is withdrawn.
Aarhus University’s ambition is to be an attractive and inspiring workplace for all and to foster a culture in which each individual has opportunities to thrive, achieve and develop. We view equality and diversity as assets, and we welcome all applicants.
Letter of reference
If you want a referee to upload a letter of reference on your behalf, please state the referee’s contact information when you submit your application. We strongly recommend that you make an agreement with the person in question before you enter the referee’s contact information, and that you ensure that the referee has enough time to write the letter of reference before the application deadline.
Unfortunately, it is not possible to ensure that letters of reference received after the application deadline will be taken into consideration.
International applicant?
Aarhus University offers a broad variety of services for international researchers and accompanying families, including assistance with relocation and career counselling to expat partners. Please find more information about the International Staff Office and the range of services here. Aarhus University also has a Junior Researcher Association and offers career development support. You can read more about these resources here.
The application must be submitted via Aarhus University’s recruitment system, which can be accessed under the job advertisement on Aarhus University's website.
Aarhus University
Aarhus University is an academically diverse and research-intensive university with a strong commitment to high-quality research and education and the development of society nationally and globally. The university offers an inspiring research and teaching environment to its 38,000 students (FTEs) and 8,300 employees, and has an annual revenues of EUR 935 million. Learn more at www.international.au.dk/
INFORMATIONER OM STILLINGEN:
- Arbejdspladsen ligger i:
Aarhus Kommune
-Virksomheden tilbyder:
-Arbejdsgiver:
Aarhus Universitet, Høegh-Guldbergs Gade 10, 8000 Aarhus C
-Ansøgning:
Ansøgningsfrist: 23-10-2023; - ansøgningsfristen er overskredet
Se mere her: https://job.jobnet.dk/CV/FindWork/Details/5913652