BEMÆRK: Ansøgningsfristen er overskredet
Applicants are invited for a PhD fellowship/scholarship at Graduate School of Technical Sciences, Aarhus University, Denmark, within the Biological and Chemical Engineering programme. The position is available from 1 April 2024 or later. You can submit your application via the link under 'how to apply'.
Title:
Optimisation of metabolism of Bacillus methanolicus to prevent CO2 loss during methanol-based growth
Research area and project description:
You will be part of project CO2MOS: CO2 Metabolism Optimisation Strategy to prevent CO2 loss during methanol assimilation. In this project a methylotrophic bacterium, Bacillus methanolicus, will be used as a model organism. B. methanolicus is a next candidate to become industrial workhorse for methanol-based production of value-added compounds. It is able to grow on methanol as sole carbon and energy source. However, it was previously observed that large proportion of carbon is lost in form of CO2 during methanol-based growth. In CO2MOS, we will identify the major contributors to CO2 loss in B. methanolicus using genome scale model of its metabolism and we will implement necessary changes in its genome to prevent it. This way, we will create a microbial strain that can be used for establishing efficient methanol-based bioproduction processes, solving an urgent issue of raw materials scarcity. the pathways contributing to carbon loss, and creation of respective deletion strains. The strain characterization will include metabolic flux analysis in collaboration international partner and evaluation of the feasibility for production of value-added compounds.
Project description.
For technical reasons, you must upload a project description. Please simply copy the project description above and upload it as a PDF in the application.
Qualifications and specific competences:
The ideal candidate has initiated or completed a relevant Masters’ degree in biotechnology, microbiology, biological engineering, molecular biology or other relevant subjects.
We are looking for a motivated PhD candidate interested in metabolic engineering. The project combines use of GSM for strain design, strain engineering and advanced strain characterisation including batch and fed-batch fermentations and metabolic flux analysis.
The preferred candidate meets following criteria:
- experimental experience in molecular biology work
- microbial cultivation techniques
- analytical techniques for liquids
- excellence in both written and spoken English
You will be working in the research group “Microbial Synthetic Biology” as part of the Dept. of Biological & Chemical Engineering. As a group member you will be expected to be a team player, where you contribute to student co-supervision, teaching and day-to-day work of the group.
Place of employment and place of work:
The place of employment is Aarhus University, and the place of work is Gustav Wieds Vej 10, 8000 Aarhus C
Contacts:
Applicants seeking further information are invited to contact:
- Associate professor Clarissa Schwab, schwab@bce.au.dk (main supervisor)
- Assistant professor Marta Irla, marta.irla@bce.au.dk (co-supervisor)
How to apply:
Please follow this link to submit your application.
Application deadline is 14 January 2024 at 23:59 CET.
Preferred starting date is 1 April 2024.
For information about application requirements and mandatory attachments, please see our application guide.
Please note:
- Only documents received prior to the application deadline will be evaluated. Thus, documents sent after deadline will not be taken into account.
- The programme committee may request further information or invite the applicant to attend an interview.
- Shortlisting will be used, which means that the evaluation committee only will evaluate the most relevant applications.
Aarhus University’s ambition is to be an attractive and inspiring workplace for all and to foster a culture in which each individual has opportunities to thrive, achieve and develop. We view equality and diversity as assets, and we welcome all applicants. All interested candidates are encouraged to apply, regardless of their personal background. Salary and terms of employment are in accordance with applicable collective agreement.
INFORMATIONER OM STILLINGEN:
- Arbejdspladsen ligger i:
Aarhus Kommune
-Virksomheden tilbyder:
-Arbejdsgiver:
Aarhus Universitet, Nordre Ringgade, 8000 Aarhus C
-Ansøgning:
Ansøgningsfrist: 14-01-2024; - ansøgningsfristen er overskredet
Se mere her: https://job.jobnet.dk/CV/FindWork/Details/5959482