BEMÆRK: Ansøgningsfristen er overskredet
The Department of Biomedicine at Faculty of Health at Aarhus University invites applications for a position as Postdoc in the field of signal transduction in innate immunology as per May 1 2024 or as soon as possible thereafter. The position is a fixed-term full-time position for 24 month.
About the research project
The molecular mechanisms that govern signalling by pattern recognition receptors of the innate immune system is a central determinant for the ability of cells and tissues to respond to infections. Therefore, there is a need to gain deep insight into how pattern recognition receptors signal at the molecular level. This will advance understanding of disease, and facilitate the development of new therapies. This project aims to uncover new molecular understanding of how the DNA-activated GAS-STING pathway instigates and regulates signaling.
Your job responsibilities
As Postdoc in signal transduction in innate immunology your position is primarily research-based but may also involve teaching assignments. You will contribute to the development of the department through research of high international quality. In your daily work, you will work closely with colleagues on your project, where you will receive supervision and guidance.
Your main tasks will consist of:
- Independent research of high international quality, including publication.
You will report to Professor Søren Riis Paludan.
Your competences
You have academic qualifications at PhD level, preferably within one or more of the following areas molecular and cellular biology, preferentially with experience in innate immunology research. We are looking for a person with hands-on experience with methods in molecular and cellular biology, such as CRISPR/Cas9 genome-editing, reporter gene assays, and protein-protein interaction assays. Applicants with previous experience, and accompanying publications, within the area of signal transduction by pattern recognition receptors will be preferred.
As a person, you are ambitious, take ownership and possess good communication and interpersonal skills. We expect you to be fluent in oral and written English.
In order to be assessed as qualified for a Postdoc position, you must meet these academic criteria.
Shortlisting will be used.
The Department of Biomedicine and the host laboratory
The Department of Biomedicine employs approx. 500 people from all over the world, and offers modern laboratory-, core- and animal facilities. The department prioritizes diversity and a good work environment, and we believe this is a prerequisite for groundbreaking research. The Department of Biomedicine provides research-based teaching of the highest quality and is responsible for a large part of the medical degree program. Moreover, the department prioritizes innovation, entrepreneurship and collaboration with business and industry. You can read more about the department here and about the faculty here.
The laboratory of Professor Søren Paludan is interested in understanding early immune responses against virus infections with focus on the CNS. For our work we use a broad range of experimental systems ranging from molecular screening tools, state-of-the-art methods for molecular/cellular characterization, animal models, and primary human cell/organoid models. We have a very international environment, with more than half of the lab members being of nationality other than Danish. The working language is English.
The laboratory is part of the Center or Immunology of Viral Infections. Our core values are high ambitions, collaborative and friendly culture, and development of talent.
Recent publications from the lab of relevance for the project:
- Zhang BC, et al. STEEP mediates STING ER exit and activation of signaling. 2020. Nature Immunology. 21: 868.
- Fruhwürth S et al. TREM2 is downregulated by HSV1 in microglia and involved in antiviral defense in the brain. 2023. Science Advances 9:eadf5808.
- Ren F et al. ER stress induces caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with HSV-2. 2023. The EMBO Journal. 42: e113118.
Questions about the position
If you have any questions about the position, please contact Søren Paludan (srp@biomed.au.dk).
Your place of work will be the Department of Biomedcine, Høegh-Guldbergs Gade 10, DK-8000 Aarhus C, Denmark.
We expect to conduct interviews first half of January.
Terms of employment
- Appointment as a postdoc requires academic qualifications at PhD level.
- Further information on the appointment procedure can be found in the Ministerial Order on the Appointment of Academic Staff at Universities.
- The appointment is in accordance with the Danish Confederation of Professional Associations (Akademikerne).
- Remuneration is in accordance with the above, and the Salary agreement catalogue for staff at Health.
- The yearly base salary for a fulltime postdoc is between DKK 484.214,84 and DKK 538.720,20 depending on the years of working experience after achieved MSc degree. The base salary includes a position related supplement and pension (17.1 %). Additional supplement(s) for special qualifications can be negotiated. Authorisation supplemement(s) will be granted, if relevant for the position. Your local eligible trade union representative at Aarhus University negotiates your salary on your behalf.
- Researchers recruited from abroad are offered a special researcher tax scheme with a lower tax rate.
- Further information on qualification requirements and job description can be found in the Ministerial Order on Job Structure for Academic Staff
Application
Your application must include the following:
- Motivated application
- Curriculum Vitae
- Diploma
- Template for applicant - postdoc
- A list of publications
- A teaching portfolio. We refer to Guideline on the use of teaching portfolios
- A maximum of five of the publications of greatest relevance to the job may be submitted (optional)
- Research plan can be uploaded (optional)
- Coauthor statement(s) can be uploaded (optional)
- References/recommendations can be uploaded separately in the e-recruitment system (optional)
Aarhus University’s ambition is to be an attractive and inspiring workplace for all and to foster a culture in which each individual has opportunities to thrive, achieve and develop. We view equality and diversity as assets, and we welcome all applicants.
Letter of reference
If you want a referee to upload a letter of reference on your behalf, please state the referee’s contact information when you submit your application. We strongly recommend that you make an agreement with the person in question before you enter the referee’s contact information, and that you ensure that the referee has enough time to write the letter of reference before the application deadline.
Unfortunately, it is not possible to ensure that letters of reference received after the application deadline will be taken into consideration.
International applicant?
Aarhus University offers a broad variety of services for international researchers and accompanying families, including assistance with relocation and career counselling to expat partners. Please find more information about the International Staff Office and the range of services here. Aarhus University also has a Junior Researcher Association and offers career development support. You can read more about these resources here.
The application must be submitted via Aarhus University’s recruitment system, which can be accessed under the job advertisement on Aarhus University's website.
Aarhus University
Aarhus University is an academically diverse and research-intensive university with a strong commitment to high-quality research and education and the development of society nationally and globally. The university offers an inspiring research and teaching environment to its 38,000 students (FTEs) and 8,300 employees, and has an annual revenues of EUR 935 million. Learn more at www.international.au.dk/
INFORMATIONER OM STILLINGEN:
- Arbejdspladsen ligger i:
Aarhus Kommune
-Virksomheden tilbyder:
-Arbejdsgiver:
Aarhus Universitet, Høegh-Guldbergs Gade 10, 8000 Aarhus C
-Ansøgning:
Ansøgningsfrist: 05-12-2023; - ansøgningsfristen er overskredet
Se mere her: https://job.jobnet.dk/CV/FindWork/Details/5944822
